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Peter Boulos
Total Earnings
$250.00
Education
Bachelors Other - Sciences University of Toronto 2015
Experience
The Princess Margaret Cancer Foundation
| Research Scientist
01 May 2014 - 01 Sep 2014 Toronto
Was involved in experimental validation of bioinformatic tools through protein immunoprecipitation techniqes, as part of a pioneering new biological theory known as ceRNA (competitive endogenous micro RNAs). Designed and implemented a bioinformatic tool that updates spreadsheet data by fetching information from an online database.
St. Michael's Hospital
| Research Science
01 Aug 2012 - 01 Apr 2013 Toronto
Was heavily involved in streamlining data analysis through Microsoft Excel spreadsheets, and various miRNA and gene bioinformatics tools such as miRPath, TargetScan 6.2 among others. Additionally, spearheaded research direction alongside post-doctoral candidates, PhD's and MD's in the medical laboratory. Finally, coordinated centralized approaches to "personalized medicine" through expression profiling methods and analysis.
Etisalat
| Data Scientist Intern
15 Jul 2013 - 01 Sep 2013 Abu Dhabi
Was involved in data analysis and segmentation in order to optimize customer pricing and improve the customer experience. Was lauded for work ethic and reliability in the work environment. This experience highlights my versatility as an employee and my willingness to apply myself to various situations effectively.
Projects & Publications
Kallikrein-related peptidase 5 induces miRNA-mediated anti-oncogenic pathways in breast cancer
01 Sep 2012 to 24 Oct 2014 Link
Kallikrein-related peptidase 5 (KLK5) displays aberrant expression in cancer. Recently, we showed KLK5 reconstitution in breast cancer cell lines suppresses malignancy. Present study aims to investigate the functional KLK5 mediated miRNA network on breast cancer progression, molecular subtype and survival. 28 miRNAs were up-regulated and 62 miRNAs were down-regulated upon KLK5 expression. Extracellular matrix (ECM) molecules and cell-adhesion pathways were the most significant KLK5-induced miRNA-mediated regulatory targets. Validation from The Cancer Genome Atlas (TCGA) database indicated KLK5 was specifically down-regulated in luminal B and basal-like breast cancer subtypes. There was a correlation between KLK5, miRNAs and their downstream ECM gene targets. Long-term patient survival correlated with dysregulation of KLK5 and interacting ECM target genes. It suggests biological differences between breast cancer molecular subtypes, patient survival, and their propensity for invasion and metastasis can be explained in part by altered miRNA networks induced by KLK5 dysregulation. We provide the first evidence that KLK5 can affect miRNA networks, which regulate MMPs and other novel ECM targets and a new compelling hypothesis of interplay between serine proteases and miRNAs. We developed a combined KLK5-(ITGB1+COL12A1) predictive score for recurrence-free survival that could be exploited in clinical applications.
Activities & Interests

- Accomplished musician (piano, guitar), and electronic music producer.
- Avid weightlifter, and squash player.
- Event organizer and host.

Other
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