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Create new tamper-resistant and abuse-deterrent medications
math & sciences chemistry science materials science biology chemical engineering pharmaceutical
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56 months ago
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Since 2009, in direct reaction to the surge in prescription opioid drug product abuse, the FDA requires risk evaluation and mitigation strategies (REMS) for all long-acting and extended-release opioid products. Many new technologies have been developed to make abuse susceptible oral drug products resistant to tampering and extraction. Common approaches include making the drug unpleasant and irritating when inhaled or injected, or causing it to lose activity when crushed.

Anchored by its well-known EUDRAGIT® product portfolio, Evonik develops polymeric coatings and matrix systems that provide reliable and targeted controlled release of active pharmaceutical ingredients from oral dosage forms (capsules, tablets). The primary functionalities include delayed and extended release, moisture protection, taste masking and solubility enhancement. In recent years, there has been an increased interest in using EUDRAGIT® polymers in new applications such as developing oral dosage formulations for abuse resistance and deterrence.

Evonik envisions use of our EUDRAGIT® polymers in developing adva