Rescue Parkinson's patients during "off" times

Parkinson's disease is a degenerative disorder of the central nervous system mainly affecting the motor system. Early in the course of the disease, the most obvious symptoms are movement-related; these include shaking, rigidity, slowness of movement and difficulty walking.

Despite optimized pharmacotherapy, patients experience more frequent fluctuations between symptomatic improvement ("on" times) and restricted motor functions ("off" times) as Parkinson's disease (PD) progresses.

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17 months ago

For rescue in “off” times, apomorphine is used as an injectable formulation. However, many patients do not follow medication guidelines for this injection, and we’d like to identify a more reliable method of delivering apomorphine.

1. Which technology or application method can we use to conveniently apply a sufficient amount of apomorphine to a PD patient during “off” times
2. How does application/dosing work with your proposed method or technology?
3. Why is your proposed method safe and compliant for the patient?

Important Notice: This medication needs to be usable by a patient that has lost control of most of their motor function. Focus on simplicity of application. Taking the apomorphine via pill, spray, standard injection, or patch will require a higher level of motor function than a patient will have during an "off" moment.

Use any charts, diagrams, images, sketches, or visuals to help communicate your idea.

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